Uncertainty Analysis of a Pharmacokinetic Modeling for Inhalation Exposure of Benzene from the Use of Groundwater at Dwelling

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2004 Vol.9, Issue 1 Preview Page Next Page

Uncertainty Analysis of a Pharmacokinetic Modeling for Inhalation Exposure of Benzene from the Use of Groundwater at Dwelling 거주지의 지하수사용에서 유래한 벤젠의 흡입노출에 대한 동적약리학 모델의 불확실성 분석: 김상준;이현호;박지연;이유진;유동한;양지원;

31 March 2004. pp. 28 ~ 38

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Abstract

This study presents the result of uncertainty and sensitivity analysis of a pharmacokinetic model which describes the distribution and removal of benzene at each organ when an indivisual inhales indoor contaminated air with benzene originated from groundwater. The pharmacokinetic model simulates the distribution of benzene deposited in organs of human body through inhalation of contaminated indoor air as well as degradation-metabolism in liver. This study focused on the uncertainty problem induced from the use of the single values for blood flow, partition coefficient, degradation constant, volume, etc. of each organ which was due to a lack of knowledge about these parameters or their measurements. To solve this problem, uncertainty analysis on the pharmacokinetic model was conducted simultaneously which would help understanding the risk assessment associated with VOCs.

Keywords

Indoor air pollution;Benzene;Physiologically based pharmacokinetic model;Uncertainty analysis;Sensitivity analysis;

본 연구는 지하수로부터 유래한 벤젠이 실내공기에 휘발되어 호흡을 통하여 인체에 유입될때 각 장기에 분포하고 제거되는 것을 묘사하는 동적약리학 모델의 불확실성 및 중요도 분석의 결과를 제공하였다. 오염된 실내공기의 호흡을 통해 체내에 유입된 벤젠이 각 장기에 분포하는 비율과 농도를 모의하기 위해 기존의 동적약리학 모델을 적용하였으며 간에서의 분해대사를 포함하여 구성하였다. 본 연구는 동적약리학 모델의 각 장기의 혈류량, 분배계수, 분해상수, 부피 등과 같은 인자들에 대한 지식 및 측정의 부족에서 오는 고정된 단일 값의 사용이 야기하는 불확실성 문제에 대해 초점을 맞추었다. 이를 해결하기 위해서 동적약리학 모델과 불확실성 분석을 동시에 수행되었으며 앞으로 휘발성 유기화합물과 관련한 위해도 평가에서의 이해를 높일 수 있다고 생각된다.

키워드

실내공기오염;벤젠;동적약리학 모델;불확실성 분석;중요도 분석;

References

환경부, 2001 특정오염유발시설 설치신고. 검사실적, available at http://www.me.go.kr
'Biodegradation of gasoline additives MTBE (Methyl-tert-Butyl Ether) and other oxygenates', available at http://kuic.kyonggi.ac.kr/-swchang
Kao, C.M. and Wang C.C., 'Control of BTEX migration by intrinsic bioremediation at a gasoline spill site', Water Research, 34(13), 3413-3423 (2000)10.1016/S0043-1354(00)00070-1
Choi, K-Y., Yu, D., Yang, J.-W., 'Health risk assessment of oil leakage from a gas station', J. of KSEE, 21(9), 1761-1771 (1999)
Nakayama, A., Koyoshi, S., Morisawa, S., and Yagi, T., 'Comparison of the mutations induced by p-benzoquinone, a benzene metabolite, in human and mouse cells', Mutation Research, 470(2), 147-153 (2000)10.1016/S1383-5718(00)00099-1
Spengle, J.D. and Dockery, D.W., 'Personal exposure to respirable particulates and sulfates', Journal of Air Pollution Control Association, 31, 153-159 (1981)10.1080/00022470.1981.10465205
Yu, D., Lee, H. S., Kim, S.-J., and Yang, J.-W, 'Risk assessment of indoor pollution by BTEX released from groundwater', J. KOSAE, 18, 373-381 (2002)
Kim, S.-J., Cho, H.-J., Park, J.-Y., Yang, J.-W., and Yu, D., 'A physiologically based pharmacokinetic model for contaminated indoor air from groundwater containing BTEX by inhalation pathway', J. of KSEE. 24, 1465-1478 (2002)
Travis, C.C., Quillen, J.L., and Arms, A.D., 'Pharmacokinetic of benzene', Toxicol. Appl. Pharmacol, 102, 400-420 (1990)10.1016/0041-008X(90)90037-U
Tardif, R., Charest-tardif, G., Brodeur, L., and Krishnan, K, 'Physiologically based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and human', Toxicol. Appl. Phannacol, 144, 120-134 (1997)10.1006/taap.1996.8096
Haddad, S., Tardif, R., CharestTardif, G., and Krishnan, K, 'Physiological modeling of the toxico-kinetic interactions in a quaternary mixture of aromatic hydrocarbon', Toxicol. Appl. Phannacol, 161(3), 249-257 (1999)10.1006/taap.1999.8803
Yu, D., Lee, HS., Kim, S.-J., and Yang, J.-W., 'Sensitivity and uncertainty analysis of two-compartment model for the indoor radon pollution', J. KOSAE, 18, 327-334 (2002)
McKone, T.E., 'Human exposure to volatile organic compounds in household tap water: the indoor inhalation pathway', Environ. Sci. Technol., 21, 1194-1201 (1987)10.1021/es00165a006
Bogen, KT. and McKone, T.E., 'Linking indoor air and pharmacokinetic models to assess tetrachloroethylene risk', Risk analysis, 8(4), 509-520 (1988)10.1111/j.1539-6924.1988.tb01191.x

Information

Publisher :The Korean Society of Soil and Groundwater Environment
Publisher(Ko) :한국지하수토양환경학회
Journal Title :Journal of Soil and Groundwater Environment
Journal Title(Ko) :지하수토양환경
Volume : 9
No :1
Pages :28 ~ 38

[1] 환경부, 2001 특정오염유발시설 설치신고. 검사실적, available at http://www.me.go.kr

[2] 'Biodegradation of gasoline additives MTBE (Methyl-tert-Butyl Ether) and other oxygenates', available at http://kuic.kyonggi.ac.kr/-swchang

[3] Kao, C.M. and Wang C.C., 'Control of BTEX migration by intrinsic bioremediation at a gasoline spill site', Water Research, 34(13), 3413-3423 (2000)10.1016/S0043-1354(00)00070-1

[4] Choi, K-Y., Yu, D., Yang, J.-W., 'Health risk assessment of oil leakage from a gas station', J. of KSEE, 21(9), 1761-1771 (1999)

[5] Nakayama, A., Koyoshi, S., Morisawa, S., and Yagi, T., 'Comparison of the mutations induced by p-benzoquinone, a benzene metabolite, in human and mouse cells', Mutation Research, 470(2), 147-153 (2000)10.1016/S1383-5718(00)00099-1

[6] Spengle, J.D. and Dockery, D.W., 'Personal exposure to respirable particulates and sulfates', Journal of Air Pollution Control Association, 31, 153-159 (1981)10.1080/00022470.1981.10465205

[7] Yu, D., Lee, H. S., Kim, S.-J., and Yang, J.-W, 'Risk assessment of indoor pollution by BTEX released from groundwater', J. KOSAE, 18, 373-381 (2002)

[8] Kim, S.-J., Cho, H.-J., Park, J.-Y., Yang, J.-W., and Yu, D., 'A physiologically based pharmacokinetic model for contaminated indoor air from groundwater containing BTEX by inhalation pathway', J. of KSEE. 24, 1465-1478 (2002)

[9] Travis, C.C., Quillen, J.L., and Arms, A.D., 'Pharmacokinetic of benzene', Toxicol. Appl. Pharmacol, 102, 400-420 (1990)10.1016/0041-008X(90)90037-U

[10] Tardif, R., Charest-tardif, G., Brodeur, L., and Krishnan, K, 'Physiologically based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and human', Toxicol. Appl. Phannacol, 144, 120-134 (1997)10.1006/taap.1996.8096

[11] Haddad, S., Tardif, R., CharestTardif, G., and Krishnan, K, 'Physiological modeling of the toxico-kinetic interactions in a quaternary mixture of aromatic hydrocarbon', Toxicol. Appl. Phannacol, 161(3), 249-257 (1999)10.1006/taap.1999.8803

[12] Yu, D., Lee, HS., Kim, S.-J., and Yang, J.-W., 'Sensitivity and uncertainty analysis of two-compartment model for the indoor radon pollution', J. KOSAE, 18, 327-334 (2002)

[13] McKone, T.E., 'Human exposure to volatile organic compounds in household tap water: the indoor inhalation pathway', Environ. Sci. Technol., 21, 1194-1201 (1987)10.1021/es00165a006

[14] Bogen, KT. and McKone, T.E., 'Linking indoor air and pharmacokinetic models to assess tetrachloroethylene risk', Risk analysis, 8(4), 509-520 (1988)10.1111/j.1539-6924.1988.tb01191.x

Journal of Soil and Groundwater Environment ISSN:1598-6438(Print) 2287-8831(Online) 지하수토양환경

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